Nehardea was an important Jewish centre at least from the early first century CE. Flavius Jospehus describes Nehardea as the centre of Jewish sovereignty, under the leadership of the brothers Hasinai and Hanilai, who exercised authority around the years 20-35 CE.
It was the site of a famous Talmudic academy, which was destroyed in 259 CE. Most of its scholars then moved to the academy at Pumbedita.
Ancient city of Nehardea